The testosterone effect of ibuprofen
https://www.ergo-log.com/testosteroneibuprofen.html
"The painkillers ibuprofen and diclofenac probably cause a temporary boost in testosterone levels, if the results of a 2009 Finnish-Swedish in vitro study published in Steroids are anything to go by....
Two key enzymes in the breakdown of testosterone are UGT2B17 and UGT2B15. They attach sugar groups to the testosterone molecules, which enables the kidneys to eliminate them.If the enzymes work less hard then there might just be more testosterone circulating in your body.
If the UGT2B17 enzyme isn't working (EDIT: Or presumably, doesn't have to work as hard), the urine contains relatively little sugared testosterone [structural formula shown below]. The glycosylation of epitestosterone is the work of a different enzyme....
[Hmm. We wonder whether there's some naturally occurring substance that works in the same way as ibuprofen…]
Source:
Steroids. 2009 Nov;74(12):971-7.
COMMENTARY: You can't see the graphic here, of the test molecule with sugars attached. You can in the Ergo-log article. Here's why this MIGHT be important:
Saponins from Tribulus Terrestris and other plants have one or more sugar side chains attached. This graphic illustrates a scary resemblance to the "sugared testosterone", in the Ergo-Log article. It also resembles most Ecdysterones, with that long tail and many OH groups coming off the end.
Take a gander...
SAPONINS
https://www.phytochemicals.info/phytoche ... ponins.php
SAPONINS IN RCE
https://www.jipb.net/pubsoft/content/2/2 ... 6(PS2).pdf
What does this tell us?
If those enzymes mentioned needn't work as hard attaching sugar groups (by virtue of the fact they're already present, given saponin intake) from Tribulus as found in Adaptogen N and/or RCE as found in Kre-Anabolyn, Ebol or Synthagen - it MAY be a plausible explanation for the higher test levels seen in the studies done on both. Moreso I'd say for Trib, but you get my point.
Thought it quite interesting...
