does TMG have to be taken at the same time as DAA?

[tufluk]

My TMG caps say take 1g with my first meal, but in order to get the benefits on the DAA/TMG stack do i have to take them together at the same time?

Also can some one explain what methyl donors are, how they work ect in layman terms. I know this has a lot to do with SAMe, but i want to know why it works well with DAA.

Many thanks to any help!